The main objective of this study is to assess how Coloradans with traumatic brain injury (TBI) encounter vocational rehabilitation (VR) services as they work towards competitive, integrated employment.
A Longitudinal, Multi-Dimensional Assessment of Recovery and Added Benefit of a Behavioral Health Intervention for Children with Abusive Head Trauma
This project began July 1, 2017, was granted a no-cost extension and will end June 30, 2020. Recruitment for participants continued from July 1, 2019 and discontinued January 1, 2020 due to the longitudinal nature of the study and intervention period. Between July 1, 2019 and December 31, 2019, there were 18 new admissions to […]
The core objective of this project is to improve care of children with traumatic brain injury and concern for abuse by using machine learning to recognize new patterns of brain injury that are associated with abuse and with poor outcomes. The team has developed cutting-edge MRI-based imaging methods, and are well-suited to identify new patterns […]
Initiation of an Early Exercise Program to Improve Symptoms and Psychosocial Function after Pediatric Mild Traumatic Brain Injury
The team has begun enrolling participants in a randomized clinical trial investigating the effect of early sub-symptom aerobic exercise on psychosocial outcomes, and monitoring participants for the subsequent two months. Data thus far indicates a beneficial effect of early exercise on persistent post-concussion symptoms and anxiety, relative to standard-of-care. However, these data are preliminary and […]
Microbiome, Inflammation, and Gut Permeability: The Onset of Psychiatric Conditions Among Those with Acute Mild Traumatic Brain Injury (mTBI)
This project aims to explore impact of acute mTBI on the human microbiome and the effects of the human microbiome on mental health outcomes post-injury. Since the start of this longitudinal study, regulatory approval has been obtained and study personnel were hired and trained. Nine participants have been recruited. Initial samples at baseline were obtained […]
Here we would write a quick few sentences describing the grant objectives. Please try and keep the description to around 300 words or less. Here we would write a quick few sentences describing the grant objectives. Please try and keep the description to around 300 words or less. Here we would write a quick few sentences describing the grant objectives. Please try and keep the description to around 300 words or less.
Hypocretin Replacement as a Countermeasure for Sleep-Wake Disturbances in a Mouse Model of Traumatic Brain Injury
The effects of traumatic brain injury persist far longer than just the acute, post-injury period. Individuals suffering TBI often complain of disrupted sleep, which effects cognitive performance and mood, among other symptoms. These symptoms may persist for years or decades. This project tests the hypothesis that replacement of a key brain chemical will alleviate post-TBI […]